MassMatrix creates high-throughput, analytical solutions for complex biodata that accelerate advances in science to improve and save people’s lives. Tailored to the unique needs of pharmaceutical companies and research organizations, MassMatrix combines advanced algorithms, AI, machine learning, big data and Cloud best practices, with a user-focused experience that facilitates faster access to digestible results and actionable knowledge across the enterprise.
MassMatrix’s experience with working with complex biodata started in the laboratory of Dr. Michael A. Freitas.
In order to better understand the complex PTMs patterns present on histone proteins, Dr. Freitas’ lab developed software to assist with the analysis. During development, mass spectrometers capable of rapid acquisition of high mass accuracy LC-MS/MS data sets were becoming commercially available. High mass accuracy sensitive probabilistic scoring models were developed to better rank peptide and protein matches. The resulting database search engine (mmSearch) provided important improvements in sensitivity over other similar tools with comparably low false positives when characterizing complex modified proteins. Scientists around the world continue to use mmSearch to identify complex PTM patterns for disulphide bonds and crosslinks and for hierarchical MSn (n>=3) analysis useful in phosphopeptides.